Pulmozyme Efficacy & Tolerability: Tolerability Profile

Adverse reactions are rare (1<1000) at the recommended dose of 2.5mg OD (corresponding to 2500 U)¹

Most adverse reactions are mild and transient, and did not require dose modifications
Few patients discontinued Pulmozyme due to an adverse event
Discontinuation rate for Pulmozyme (3%) was similar to that for placebo (2%)
Patients who experience adverse events common to cystic fibrosis can, in general, safely continue administration of Pulmozyme as evidenced by the high percentage of patients completing clinical trials with Pulmozyme
Upon initiation of dornase alfa therapy, as with any aerosol, pulmonary function may decline and expectoration of sputum may increase
Less than 5% of patients have developed antibodies to Pulmozyme
- No patients have developed immunoglobulin E (IgE) antibodies to Pulmozyme

Pulmozyme can be effectively and safely used in conjunction with standard cystic fibrosis therapies such as antibiotics, bronchodilators, pancreatic enzymes, vitamins, inhaled and systemic corticosteroids, and analgesics.
Pulmozyme is contraindicated in patients with known hypersensitivity to dornase alfa, Chinese Hamster Ovary cell products, or any component of the product.
Please refer to the SmPC for full prescribing information.

EU SmPC

1. Pulmozyme SmPC, Electronic Medicines Compendium, accessed 10/8/18

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